Retinal Photodamage by Endogenous and Xenobiotic Agents†
نویسندگان
چکیده
منابع مشابه
Retinal photodamage by endogenous and xenobiotic agents.
The human eye is constantly exposed to sunlight and artificial lighting. Light transmission through the eye is fundamental to its unique biological functions of directing vision and circadian rhythm and therefore light absorbed by the eye must be benign. However, exposure to the very intense ambient radiation can pose a hazard particularly if the recipient is over 40 years of age. There are age...
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During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure-function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The r...
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ژورنال
عنوان ژورنال: Photochemistry and Photobiology
سال: 2012
ISSN: 0031-8655
DOI: 10.1111/j.1751-1097.2012.01174.x